Senior Scientist - Medicinal Chemistry

1w1 week ago

Amgen

South San Francisco, US · Full-time · $142,079 – $192,225

About this role

At Amgen, join the shared mission to serve patients living with serious illnesses. As part of the innovative Medicinal Chemistry group, design, synthesize, and purify novel compounds for potential clinical drug development. Help pioneer biotech against tough diseases in oncology, inflammation, general medicine, and rare disease.

In this onsite laboratory role at the South San Francisco site, work within Amgen’s Induced Proximity Platform focused on PROTAC modality for intractable targets. Devise state-of-the-art research through experiments and detailed project planning with timelines and milestones. Analyze scientific data to drive innovative medicines.

Thrive in Amgen’s award-winning collaborative, innovative, and science-based culture. Collaborate with scientists, provide updates, and stay current with literature and technology developments. Participate in national and international meetings while mentoring research associates.

Transform patient lives and your career by generating publications, patents, and lasting impact. Advise colleagues in expertise areas and embrace challenges for opportunities in drug discovery. Reach millions of patients yearly through research, manufacturing, and delivery of therapies.

Requirements

Doctorate degree OR Master’s degree and 3 years of laboratory experience OR Bachelor’s degree and 5 years of laboratory experience
Doctorate degree in chemistry specializing in organic synthesis
2+ years of experience in synthetic organic or medicinal chemistry
Consistent track record of academic accomplishments (e.g., peer-reviewed publications and/or patents)
Demonstration of good lab practices, with particular attention to safety
Clear understanding of structural determination using NMR and MS techniques as well as knowledge of related purification methods
Initial understanding of biological and pharmaceutical principles and working knowledge of structure-based or other computer-aided drug design tools
Knowledge of the application of parallel synthesis techniques to synthetic or medicinal chemistry

Responsibilities

Design, synthesize, and purify novel compounds for potential clinical drug development
Work within Amgen’s Induced Proximity Platform (IPP) on PROTAC modality for intractable targets
Devise and implement state-of-the-art scientific research through conducting laboratory experiments
Plan detailed procedures for defined projects including timelines, milestones, methodological approaches, expected results, and necessary resources
Review, analyze, and interpret scientific data and results
Provide regular updates, documentation, and communication on project results
Collaborate with other scientists and keep current with field of expertise including literature and technology development
Advise supervisors and colleagues in areas of expertise, participate in meetings, support publications or patents, and mentor research associates